{"id":59419,"date":"2026-06-09T00:50:35","date_gmt":"2026-06-08T21:50:35","guid":{"rendered":"https:\/\/saglikdanisma.net\/is\/trikloretilen-ve-klorlu-cozuculer-hepatotoksisite-ve-norotoksisite\/"},"modified":"2026-06-18T00:17:34","modified_gmt":"2026-06-17T21:17:34","slug":"trikloretilen-ve-klorlu-cozuculer-hepatotoksisite-ve-norotoksisite","status":"publish","type":"post","link":"https:\/\/saglikdanisma.net\/is\/trikloretilen-ve-klorlu-cozuculer-hepatotoksisite-ve-norotoksisite\/","title":{"rendered":"Trikloretilen ve Klorlu \u00c7\u00f6z\u00fcc\u00fcler: Hepatotoksisite ve N\u00f6rotoksisite"},"content":{"rendered":"<div class=\"makale\">\n<p>Trikloretilen (TCE) ve trikloretan (TCA), metal ya\u011f alma, kuru temizleme, yap\u0131\u015ft\u0131r\u0131c\u0131 \u00fcretimi ve di\u011fer end\u00fcstriyel i\u015flemlerde yayg\u0131n olarak kullan\u0131lan klorlu \u00e7\u00f6z\u00fcc\u00fclerdir. Bu kimyasallar\u0131n hepatotoksisite (karaci\u011fere toksik etki) ve n\u00f6rotoksisite (sinir sistemine toksik etki) potansiyelleri nedeniyle i\u015fyeri hekimleri taraf\u0131ndan dikkatle takip edilmesi gereken \u00f6nemli bir meslek hastal\u0131\u011f\u0131 risk fakt\u00f6r\u00fcd\u00fcr.<\/p>\n<p><strong>Etken Maddeler ve Kullan\u0131m Alanlar\u0131<\/strong><\/p>\n<p><strong>Trikloretilen (TCE)<\/strong><\/p>\n<ul>\n<li><strong>Kimyasal \u00d6zellikler:<\/strong> Renksiz, u\u00e7ucu, stabil bir s\u0131v\u0131.<\/li>\n<li><strong>Kullan\u0131m Alanlar\u0131:<\/strong> Metal ya\u011f alma (\u00f6zellikle hassas par\u00e7alar\u0131n temizli\u011finde), kuru temizleme, yap\u0131\u015ft\u0131r\u0131c\u0131 \u00fcretimi, tekstil end\u00fcstrisi, buharla temizleme i\u015flemlerinde kullan\u0131l\u0131r.<\/li>\n<li><strong>G\u00f6r\u00fclme S\u0131kl\u0131\u011f\u0131:<\/strong> End\u00fcstriyel alanlarda yayg\u0131n olarak kullan\u0131l\u0131r.<\/li>\n<\/ul>\n<p><strong>Trikloretan (TCA)<\/strong><\/p>\n<ul>\n<li><strong>Kimyasal \u00d6zellikler:<\/strong> Renksiz, u\u00e7ucu, stabil bir s\u0131v\u0131.<\/li>\n<li><strong>Kullan\u0131m Alanlar\u0131:<\/strong> Metal ya\u011f alma, kuru temizleme, yap\u0131\u015ft\u0131r\u0131c\u0131 \u00fcretimi, tekstil end\u00fcstrisi, boya s\u00f6k\u00fcc\u00fc, vernik \u00e7\u00f6z\u00fcc\u00fc olarak kullan\u0131l\u0131r.<\/li>\n<li><strong>G\u00f6r\u00fclme S\u0131kl\u0131\u011f\u0131:<\/strong> End\u00fcstriyel alanlarda yayg\u0131n olarak kullan\u0131l\u0131r.<\/li>\n<\/ul>\n<p><strong>Toksisite ve Maruziyet S\u0131n\u0131rlar\u0131<\/strong><\/p>\n<p><strong>Trikloretilen (TCE)<\/strong><\/p>\n<ul>\n<li><strong>Hepatotoksisite:<\/strong> Karaci\u011fer hasar\u0131na neden olabilir. \u00d6zellikle y\u00fcksek konsantrasyonlarda veya uzun s\u00fcreli maruziyette hepatit tablosu geli\u015febilir.<\/li>\n<li><strong>N\u00f6rotoksisite:<\/strong> Santral sinir sistemini etkileyerek ba\u015f a\u011fr\u0131s\u0131, ba\u015f d\u00f6nmesi, sersemlik, koordinasyon bozuklu\u011fu, haf\u0131za kayb\u0131, uyku hali gibi n\u00f6rolojik semptomlara yol a\u00e7abilir.<\/li>\n<li><strong>Maruziyet S\u0131n\u0131rlar\u0131 (T\u00fcrkiye Mevzuat\u0131):<\/strong>\n<ul>\n<li>TWA (8 saat): 10 ppm (54 mg\/m\u00b3)<\/li>\n<li>STEL (15 dakika): 25 ppm (162 mg\/m\u00b3)<\/li>\n<\/ul>\n<\/li>\n<li><strong>Biyolojik \u0130zlem:<\/strong> \u0130drarda trikloroasetik asit (TCA) \u00f6l\u00e7\u00fcm\u00fc yap\u0131labilir.<\/li>\n<\/ul>\n<p><strong>Trikloretan (TCA)<\/strong><\/p>\n<ul>\n<li><strong>Hepatotoksisite:<\/strong> Karaci\u011fer hasar\u0131na neden olabilir.<\/li>\n<li><strong>N\u00f6rotoksisite:<\/strong> Santral sinir sistemini etkileyerek ba\u015f a\u011fr\u0131s\u0131, ba\u015f d\u00f6nmesi, sersemlik gibi semptomlara yol a\u00e7abilir.<\/li>\n<li><strong>Maruziyet S\u0131n\u0131rlar\u0131 (T\u00fcrkiye Mevzuat\u0131):<\/strong>\n<ul>\n<li>TWA (8 saat): 5 ppm (28 mg\/m\u00b3)<\/li>\n<li>STEL (15 dakika): 25 ppm (140 mg\/m\u00b3)<\/li>\n<\/ul>\n<\/li>\n<li><strong>Biyolojik \u0130zlem:<\/strong> \u0130drarda trikloroasetik asit (TCA) \u00f6l\u00e7\u00fcm\u00fc yap\u0131labilir.<\/li>\n<\/ul>\n<p><strong>Klinik Tablo ve Tan\u0131 Kriterleri<\/strong><\/p>\n<p><strong>Trikloretilen (TCE) Maruziyetinde Klinik Tablo:<\/strong><\/p>\n<ul>\n<li><strong>Akut Maruziyet:<\/strong> Ba\u015f a\u011fr\u0131s\u0131, ba\u015f d\u00f6nmesi, sersemlik, mide bulant\u0131s\u0131, kusma, kar\u0131n a\u011fr\u0131s\u0131, uyku hali, haf\u0131za kayb\u0131, koordinasyon bozuklu\u011fu, konu\u015fma g\u00fc\u00e7l\u00fc\u011f\u00fc, kaslarda se\u011firme, deride k\u0131zar\u0131kl\u0131k ve uyu\u015fma.<\/li>\n<li><strong>Kronik Maruziyet:<\/strong> Karaci\u011fer fonksiyon bozukluklar\u0131 (sar\u0131l\u0131k, hepatit), n\u00f6rolojik bulgular (periferik n\u00f6ropati, ensefalopati), dermatit, b\u00f6brek fonksiyon bozukluklar\u0131, psikolojik etkiler (depresyon, anksiyete, haf\u0131za kayb\u0131) g\u00f6r\u00fclebilir.<\/li>\n<\/ul>\n<p><strong>Trikloretan (TCA) Maruziyetinde Klinik Tablo:<\/strong><\/p>\n<ul>\n<li><strong>Akut Maruziyet:<\/strong> Ba\u015f a\u011fr\u0131s\u0131, ba\u015f d\u00f6nmesi, sersemlik, mide bulant\u0131s\u0131, kusma, kar\u0131n a\u011fr\u0131s\u0131, uyku hali, haf\u0131za kayb\u0131, koordinasyon bozuklu\u011fu, konu\u015fma g\u00fc\u00e7l\u00fc\u011f\u00fc, kaslarda se\u011firme, deride k\u0131zar\u0131kl\u0131k ve uyu\u015fma.<\/li>\n<li><strong>Kronik Maruziyet:<\/strong> Karaci\u011fer fonksiyon bozukluklar\u0131 (sar\u0131l\u0131k, hepatit), n\u00f6rolojik bulgular (periferik n\u00f6ropati, ensefalopati), dermatit, b\u00f6brek fonksiyon bozukluklar\u0131, psikolojik etkiler (depresyon, anksiyete, haf\u0131za kayb\u0131) g\u00f6r\u00fclebilir.<\/li>\n<\/ul>\n<p><strong>Tan\u0131 Kriterleri:<\/strong><\/p>\n<ul>\n<li>\u00d6yk\u00fcde maruziyetin varl\u0131\u011f\u0131,<\/li>\n<li>Klinik bulgular,<\/li>\n<li>Biyolojik izlem sonu\u00e7lar\u0131 (idrarda TCA \u00f6l\u00e7\u00fcm\u00fc).<\/li>\n<\/ul>\n<p><strong>Meslek Hastal\u0131\u011f\u0131 Bildirimi ve SGK S\u00fcreci (T\u00fcrkiye Mevzuat\u0131)<\/strong><\/p>\n<p><strong>Bildirim Y\u00fck\u00fcml\u00fcl\u00fc\u011f\u00fc:<\/strong><\/p>\n<ul>\n<li>\u0130\u015f kazas\u0131 veya meslek hastal\u0131\u011f\u0131 \u015f\u00fcphesi veya tan\u0131s\u0131 alan bir \u00e7al\u0131\u015fan\u0131n SGK&#8217;ya bildirimi, hastal\u0131\u011f\u0131n \u00f6\u011frenilmesinden sonraki \u00fc\u00e7 i\u015f g\u00fcn\u00fc i\u00e7inde zorunludur.<\/li>\n<li>Bu bildirim i\u00e7in \u201c\u0130\u015f Kazas\u0131 ve Meslek Hastal\u0131\u011f\u0131 Bildirim Formu\u201d (\u00c7SGB taraf\u0131ndan sa\u011flanan form) kullan\u0131lmal\u0131d\u0131r.<\/li>\n<\/ul>\n<p><strong>SGK S\u00fcreci:<\/strong><\/p>\n<ul>\n<li>Bildirimler SGK&#8217;ya yap\u0131ld\u0131ktan sonra, SGK taraf\u0131ndan gerekli incelemeler ve de\u011ferlendirmeler yap\u0131l\u0131r.<\/li>\n<li>Meslek hastal\u0131\u011f\u0131 tan\u0131s\u0131 konulmas\u0131 durumunda, ilgili mevzuat \u00e7er\u00e7evesinde sigortal\u0131n\u0131n haklar\u0131 (tedavi, i\u015f g\u00f6remezlik \u00f6dene\u011fi vb.) belirlenir.<\/li>\n<li>\u0130\u015fyeri hekiminin, meslek hastal\u0131\u011f\u0131 veya i\u015f kazas\u0131 ge\u00e7iren \u00e7al\u0131\u015fan\u0131n durumunu ve i\u015fe d\u00f6n\u00fc\u015f\u00fcn\u00fc de\u011ferlendirerek raporlamas\u0131, SGK s\u00fcre\u00e7lerinde \u00f6nemli bir ad\u0131md\u0131r.<\/li>\n<\/ul>\n<p><strong>\u0130\u015fyeri Ziyareti, Risk De\u011ferlendirmesi ve Koruyucu \u00d6nlemler<\/strong><\/p>\n<p><strong>\u0130\u015fyeri Ziyareti:<\/strong><\/p>\n<ul>\n<li>\u0130\u015fyeri hekimi veya i\u015f g\u00fcvenli\u011fi uzman\u0131, \u00e7al\u0131\u015fma ortam\u0131n\u0131 ve kullan\u0131lan kimyasallar\u0131 yerinde g\u00f6zlemlemelidir.<\/li>\n<li>\u00d6zellikle metal ya\u011f alma ve temizleme yap\u0131lan alanlar detayl\u0131 incelenmelidir.<\/li>\n<li>Havaland\u0131rma sistemleri, ki\u015fisel koruyucu donan\u0131m (KKD) kullan\u0131m\u0131, \u00e7al\u0131\u015fma y\u00f6ntemleri ve ki\u015fisel hijyen uygulamalar\u0131 g\u00f6zlemlenmelidir.<\/li>\n<\/ul>\n<p><strong>Risk De\u011ferlendirmesi (RD):<\/strong><\/p>\n<ul>\n<li>\u0130\u015fyerinde bulunan t\u00fcm tehlikeler (fiziksel, kimyasal, biyolojik, ergonomik, psikososyal) belirlenmeli ve bu tehlikelerin riskleri analiz edilmelidir.<\/li>\n<li>Trikloretilen ve klorlu \u00e7\u00f6z\u00fcc\u00fclere maruziyet riskleri \u00f6zellikle \u00f6nceliklendirilmelidir.<\/li>\n<li>Mevcut kontrol \u00f6nlemleri (havaland\u0131rma, KKD kullan\u0131m\u0131, i\u015f rotasyonu vb.) de\u011ferlendirilmeli ve yetersiz kalanlar i\u00e7in ek \u00f6nlemler planlanmal\u0131d\u0131r.<\/li>\n<li>Malzeme G\u00fcvenlik Bilgi Formlar\u0131 (MSDS) mutlaka temin edilmeli ve i\u00e7eri\u011fine hakim olunmal\u0131d\u0131r.<\/li>\n<\/ul>\n<p><strong>Koruyucu \u00d6nlemler:<\/strong><\/p>\n<ul>\n<li><strong>M\u00fchendislik Kontrolleri:<\/strong>\n<ul>\n<li>Kapal\u0131 sistemlerde \u00e7al\u0131\u015fma veya yerel havaland\u0131rma sistemleri kurulmas\u0131,<\/li>\n<li>Temizleme i\u015flemlerinde daha az riskli kimyasallar\u0131n kullan\u0131lmas\u0131,<\/li>\n<li>Otomatik ekipmanlar\u0131n kullan\u0131lmas\u0131,<\/li>\n<li>Maruziyet s\u00fcresinin azalt\u0131lmas\u0131 (i\u015f rotasyonu, dinlenme aralar\u0131).<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u0130dari Kontroller:<\/strong>\n<ul>\n<li>\u00c7al\u0131\u015fanlar\u0131n e\u011fitilmesi,<\/li>\n<li>Ki\u015fisel hijyenin sa\u011flanmas\u0131,<\/li>\n<li>KKD kullan\u0131m\u0131n\u0131n sa\u011flanmas\u0131 ve denetlenmesi.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Ki\u015fisel Koruyucu Donan\u0131m (KKD):<\/strong>\n<ul>\n<li>Solunum maskeleri (uygun tipte),<\/li>\n<li>Koruyucu g\u00f6zl\u00fckler,<\/li>\n<li>Kimyasallara dayan\u0131kl\u0131 eldivenler.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><strong>Pratik Uygulama ve Vaka Yakla\u015f\u0131m\u0131<\/strong><\/p>\n<p><strong>Vaka \u00d6rne\u011fi:<\/strong> Bir metal i\u015fleme at\u00f6lyesinde \u00e7al\u0131\u015fan bir i\u015f\u00e7ide, uzun s\u00fcreli trikloretilen maruziyeti nedeniyle hepatotoksisite ve n\u00f6rotoksisite geli\u015fti\u011fi \u015f\u00fcphesiyle i\u015fyeri hekimine ba\u015fvurdu. \u0130\u015fyeri hekimi, i\u015f\u00e7inin \u00e7al\u0131\u015ft\u0131\u011f\u0131 ortam\u0131 ve kulland\u0131\u011f\u0131 kimyasallar\u0131 de\u011ferlendirdi. \u00c7al\u0131\u015fan\u0131n idrar TCA d\u00fczeyleri y\u00fcksek bulundu ve karaci\u011fer enzimlerinde de y\u00fckselme tespit edildi. \u0130\u015fyeri hekimi, i\u015f\u00e7inin trikloretilen maruziyetini azaltmak i\u00e7in havaland\u0131rma sisteminin iyile\u015ftirilmesi ve i\u015f rotasyonu gibi \u00f6nlemlerin al\u0131nmas\u0131n\u0131 \u00f6nerdi. Ayr\u0131ca i\u015f\u00e7iye KKD kullan\u0131m\u0131 ve ki\u015fisel hijyen konusunda e\u011fitim verildi. SGK bildirimi yap\u0131ld\u0131.<\/p>\n<p><strong>\u00d6nemli Notlar:<\/strong><\/p>\n<ul>\n<li>Bu kimyasallara maruziyetin erken tespiti ve \u00f6nlenmesi, karaci\u011fer ve sinir sistemi sa\u011fl\u0131\u011f\u0131 a\u00e7\u0131s\u0131ndan kritik \u00f6neme sahiptir.<\/li>\n<li>\u0130\u015fyeri hekimleri, risk de\u011ferlendirmelerini g\u00fcncelleyerek ve biyolojik izlem sonu\u00e7lar\u0131n\u0131 takip ederek koruyucu \u00f6nlemleri s\u00fcrekli olarak g\u00f6zden ge\u00e7irmelidir.<\/li>\n<li>T\u00fcrkiye mevzuat\u0131nda trikloretilen ve trikloretan i\u00e7in belirlenen maruziyet s\u0131n\u0131r de\u011ferlerine uyulmal\u0131d\u0131r.<\/li>\n<\/ul>\n<p><strong>Kaynaklar<\/strong><\/p>\n<div class=\"kaynaklar\">\n<h3>Kaynaklar<\/h3>\n<ul>\n<li>T.C. Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131, Sa\u011fl\u0131k Hizmetleri Genel M\u00fcd\u00fcrl\u00fc\u011f\u00fc. (2026). Eri\u015fkinlerde \u0130\u015fitme Kay\u0131plar\u0131 Klinik Rehberi.<\/li>\n<li>Amerikan Speech-Language-Hearing Association (ASHA). (2023). Hearing loss in adults. https:\/\/www.asha.org\/public\/hearing\/hearing-loss-in-adults\/?srsltid=AfmBOoqc1Fpc6D-IiVRQ19AEL5K4cAsvCc-irXBw4_SLIimuxU_ffHIt<\/li>\n<li>World Health Organization. (2021). World Report on Hearing. Geneva, Switzerland: World Health Organization.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Trikloretilen (TCE) ve trikloretan (TCA), metal ya\u011f alma, kuru temizleme, yap\u0131\u015ft\u0131r\u0131c\u0131 \u00fcretimi ve di\u011fer end\u00fcstriyel i\u015flemlerde yayg\u0131n olarak kullan\u0131lan klorlu \u00e7\u00f6z\u00fcc\u00fclerdir. Bu &#8230; <a title=\"Trikloretilen ve Klorlu \u00c7\u00f6z\u00fcc\u00fcler: Hepatotoksisite ve N\u00f6rotoksisite\" class=\"read-more\" href=\"https:\/\/saglikdanisma.net\/is\/trikloretilen-ve-klorlu-cozuculer-hepatotoksisite-ve-norotoksisite\/\" aria-label=\"Read more about Trikloretilen ve Klorlu \u00c7\u00f6z\u00fcc\u00fcler: Hepatotoksisite ve N\u00f6rotoksisite\">Devam\u0131n\u0131 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Ayr\u0131ca \u0130stanbul b\u00f6lgesi \u0130\u015f Sa\u011fl\u0131\u011f\u0131,\u0130\u015f Kazalar\u0131 ve Meslek Hastal\u0131klar\u0131 ile bilirki\u015fi olarak g\u00f6rev yapmaktad\u0131r.","sameAs":["https:\/\/saglikdanisma.net\/is","https:\/\/www.facebook.com\/profile.php?id=61567337753415","https:\/\/www.instagram.com\/issagligi","https:\/\/www.linkedin.com\/company\/ergometri\/","https:\/\/x.com\/ergometri","https:\/\/www.youtube.com\/@issagligi"],"url":"https:\/\/saglikdanisma.net\/is\/author\/saglikdanisma\/"}]}},"_links":{"self":[{"href":"https:\/\/saglikdanisma.net\/is\/wp-json\/wp\/v2\/posts\/59419","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saglikdanisma.net\/is\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saglikdanisma.net\/is\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saglikdanisma.net\/is\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/saglikdanisma.net\/is\/wp-json\/wp\/v2\/comments?post=59419"}],"version-history":[{"count":2,"href":"https:\/\/saglikdanisma.net\/is\/wp-json\/wp\/v2\/posts\/59419\/revisions"}],"predecessor-version":[{"id":59552,"href":"https:\/\/saglikdanisma.net\/is\/wp-json\/wp\/v2\/posts\/59419\/revisions\/59552"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saglikdanisma.net\/is\/wp-json\/wp\/v2\/media\/59418"}],"wp:attachment":[{"href":"https:\/\/saglikdanisma.net\/is\/wp-json\/wp\/v2\/media?parent=59419"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saglikdanisma.net\/is\/wp-json\/wp\/v2\/categories?post=59419"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saglikdanisma.net\/is\/wp-json\/wp\/v2\/tags?post=59419"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}